Yunsun Nam

Dec 20, 2024 | science.org | Robyn Scott |Luiza Tunes |Meng-Hsiung Hsieh |Ping Wang |Ashwani Kumar |Brijesh B Khadgi | +8 more

Published In Science AdvancesVolume 10 | Issue 51December 2024Article versionsSubmission historyReceived: 14 August 2024Accepted: 14 November 2024PermissionsRequest permissions for this article. AcknowledgmentsWe thank O. Koczy, J. Parker, and R. Setlem for contributing to preliminary studies. We are grateful for the helpful discussions with B. Xhemalce on genomic data analysis. The Structural Biology Laboratory at UT Southwestern for help with synchrotron data collection.

Oct 17, 2024 | biorxiv.org | Yunsun Nam |Brijesh B Khadgi

AbstractMicroRNAs modulate most protein-coding genes, and many are regulated during maturation. Chemical modifications of primary transcripts containing microRNAs have been implicated in altering Microprocessor processing efficiency, a key initiating endonucleolytic step performed by Drosha and DGCR8.