Yunxin Xu

Nov 11, 2024 | nature.com | Yunxin Xu |Boxue Tian |Haipeng Gong |David R. Liu |Christopher A. Voigt |B. W. Thuronyi

AbstractDesigning proteins with improved functions requires a deep understanding of how sequence and function are related, a vast space that is hard to explore. The ability to efficiently compress this space by identifying functionally important features is extremely valuable. Here we establish a method called EvoScan to comprehensively segment and scan the high-fitness sequence space to obtain anchor points that capture its essential features, especially in high dimensions.