Yunye He

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Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease - Nature Cardiovascular Research

May 19, 2024 | nature.com | Marios K. Georgakis |Yunye He |Masaru Koido |Chikashi Terao

AbstractGenetic variants in HTRA1 are associated with stroke risk. However, the mechanisms mediating this remain largely unknown, as does the full spectrum of phenotypes associated with genetic variation in HTRA1. Here we show that rare HTRA1 variants are linked to ischemic stroke in the UK Biobank and BioBank Japan.

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