Marios K. Georgakis

Aug 7, 2024 | nature.com | Jiayu Cao |Stefan Roth |Anna Kopczak |Yaw Asare |Marios K. Georgakis |Jack Green | +12 more

AbstractThe risk of early recurrent events after stroke remains high despite currently established secondary prevention strategies1. Risk is particularly high in patients with atherosclerosis, with more than 10% of patients experiencing early recurrent events1,2. However, despite the enormous medical burden of this clinical phenomenon, the underlying mechanisms leading to increased vascular risk and recurrent stroke are largely unknown.

Aug 5, 2024 | mdpi.com | Yaw Asare |Marios K. Georgakis

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May 19, 2024 | nature.com | Marios K. Georgakis |Yunye He |Masaru Koido |Chikashi Terao

AbstractGenetic variants in HTRA1 are associated with stroke risk. However, the mechanisms mediating this remain largely unknown, as does the full spectrum of phenotypes associated with genetic variation in HTRA1. Here we show that rare HTRA1 variants are linked to ischemic stroke in the UK Biobank and BioBank Japan.