Yunzhou Dong

Jan 7, 2025 | biorxiv.org | Yunzhou Dong |Joshua M. Bock |Shahid Karim |Prachi Singh

AbstractAldosterone, a hormone synthesized by the adrenal glands, plays a pivotal role in regulating both blood pressure and electrolyte balance and may contribute to long term cardiovascular risk. Recent findings suggest that adipose tissue might serve as a source for aldosterone production and secretion. Patients suffering from obstructive sleep apnea (OSA) often exhibit elevated blood pressure levels and increased cardiovascular risk.

Jul 30, 2024 | biorxiv.org | Beibei Wang |Kui Cui |Bo Zhu |Yunzhou Dong

AbstractSmooth muscle cells in major arteries play a crucial role in regulating coronary artery disease. Conversion of smooth muscle cells into other adverse cell types in the artery propels the pathogenesis of the disease. Curtailing artery plaque buildup by modulating smooth muscle cell reprograming presents us a new opportunity to thwart coronary artery disease.

Jan 8, 2024 | biorxiv.org | Beibei Wang |Kui Cui |Bo Zhu |Yunzhou Dong

AbstractHypothesis: VSMC play crucial roles in atherosclerosis via phenotypic switching. The trans-differentiation of VSMC into other cell types might contribute to atherosclerotic lesion development, progression, and the subsequent diseases such as myocardial infarction or stroke. Epsins, a family of endocytic adaptors, are crucial for atherosclerosis development and progression; yet, the role of epsins in VSMC phenotypic modulation is unknown.