Yuqin Guo

May 16, 2024 | onlinelibrary.wiley.com | Yunxia Wang |Jiajia Yang |Chun Lin Wu |Yuqin Guo

1 INTRODUCTION Diabetic nephropathy (DN), a serious microvascular complication of diabetes mellitus, affects approximately 50% of patients with both type I and type II diabetes.1, 2 DN is characterized by extracellular matrix accumulation, basement membrane thickening, and glomerular hypertrophy, which are related to glomerular mesangial cell proliferation.3 Hyperglycemic factors including terminal glycosylation products contribute to excess extracellular matrix and lead to renal fibrosis.4...