Yuqing Lei

2 weeks ago | advanced.onlinelibrary.wiley.com | Tian Zhao |Yuqing Lei |Chang Liu |Dong Zhang

1 Introduction The long-term protective effects of vaccines are critically dependent on the sustained response of memory B cells (MBCs) and long-lived plasma cells (LLPCs).[1] MBCs contain B cell receptors (BCR) on their membrane surface and can rapidly differentiate into antibody-secreting cells (ASC) upon re-exposure to an antigen,[2] while LLPCs reside in the bone marrow and continuously secrete antibodies to maintain the active humoral immune response.[3] The ability to isolate and...