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2 weeks ago | 
advanced.onlinelibrary.wiley.com | Tian Zhao |Yuqing Lei |Chang Liu |Dong Zhang
1 Introduction The long-term protective effects of vaccines are critically dependent on the sustained response of memory B cells (MBCs) and long-lived plasma cells (LLPCs).[1] MBCs contain B cell receptors (BCR) on their membrane surface and can rapidly differentiate into antibody-secreting cells (ASC) upon re-exposure to an antigen,[2] while LLPCs reside in the bone marrow and continuously secrete antibodies to maintain the active humoral immune response.[3] The ability to isolate and...
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Nov 14, 2024 | 
mdpi.com | Tian Zhao
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Jun 19, 2024 | 
onlinelibrary.wiley.com | Chang Liu |Kaiyi Li |Xizhao Sui |Tian Zhao
Construction and Optimization of the Automated Single-Cell Distribution Instrument The home-built single-cell distribution instrument (SCDI) consisting of an integrated microscopy module for imaging cells, a six-axis motion and control module for operating the chip platform and the robotic arm, and a motor-controlled hydraulic microneedle module for cell delivery.
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Jun 6, 2024 | 
biorxiv.org | Kaiyi Li |Chang Liu |Ting Zhang |Tian Zhao
AbstractDeciphering the interactions between tumor micro- and systemic immune macro-environment is essential for developing more effective cancer diagnosis and treatment strategies. Here, we established a gel-liquid interface (GLI) co-culture of lung cancer organoids (LCOs) and paired peripheral blood mononuclear cells (PBMCs), featuring with enhanced interactions of immune cells and tumor organoids, to mimic the in vivo systemic anti-tumor immunity induced by immune checkpoint inhibitors (ICI).
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May 28, 2024 | 
arxiv.org | Tian Zhao
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Feb 3, 2024 | 
dx.doi.org | Tian Zhao |Haihui Sun |Shengyang Ji |Bowen Yang
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
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Feb 3, 2024 | 
pubs.acs.org | Tian Zhao |Shengyang Ji |Bowen Yang |Haihui Sun
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
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Dec 12, 2023 | 
biorxiv.org | Chang Liu |Kaiyi Li |Xizhao Sui |Tian Zhao
AbstractIn vitro models coupled with multimodal approaches are urgently needed to decipher the local tumor immune microenvironment (TIME) owing to the heterogeneous nature of immune cells and their diverse spatial distributions. Here we generate primary lung cancer organoids (pLCOs) by isolating the tumor cell clusters, including the infiltrated immune cells, from dissected lung cancer samples.
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Jul 6, 2023 | 
embopress.org | Tian Zhao |Jiaojiao Zhang |Yuanyuan Meng |Hongcheng Cheng
Mitochondrial biogenesis is the process of generating new mitochondria to maintain cellular homeostasis. Here, we report that viruses exploit mitochondrial biogenesis to antagonize innate antiviral immunity. We found that nuclear respiratory factor-1 (NRF1), a vital transcriptional factor involved in nuclear-mitochondrial interactions, is essential for RNA (VSV) or DNA (HSV-1) virus-induced mitochondrial biogenesis.
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Jun 28, 2023 | 
mdpi.com | Tian Zhao |Zhixin Liu
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticlebyTian Zhao * and Zhixin Liu School of Economics and Management, Beihang University, 37 Xueyuan Road, Beijing 100191, China*Author to whom correspondence should be addressed.
