Yusha Sun

Dec 9, 2024 | cell.com | Meghan T. Logun |Xin Wang |Yusha Sun |Stephen J. Bagley |Nannan Li |Arati Desai | +9 more

Keywordsglioblastomapatient-derived tumor organoidex vivoCAR-T cell therapyreal-time correlativeclinical trialorganoidcytokineGet full text accessLog in, subscribe or purchase for full access. References1. Drost, J. ∙ Clevers, H. Organoids in cancer researchNat. Rev. Cancer. 2018; 18:407-4182. Jiang, X. ∙ Oyang, L. ∙ Peng, Q. ... Organoids: opportunities and challenges of cancer therapyFront. Cell Dev. Biol. 2023; 11, 12325283. Wang, X. ∙ Sun, Y. ∙ Zhang, D.Y. ...

Oct 4, 2024 | biorxiv.org | Daniel Zhang |Xin Wang |Yusha Sun |Qi Cui

AbstractCAR-T therapy is a promising new immunotherapy for cancers, but its efficacy for solid tumors requires improvement. A detailed understanding of the interplay between solid tumors and CAR-T cells is critical. Here we report temporal, multi-modal, single-cell profiling of patient-derived glioblastoma organoids with CAR-T treatment.

Oct 4, 2024 | biorxiv.org | Meghan T. Logun |Xin Wang |Yusha Sun |Stephen J. Bagley

AbstractPatient-derived tumor organoids have been leveraged for disease modeling and preclinical studies, but rarely applied in real-time to aid with interpretation of patient treatment responses in clinics. We recently demonstrated early efficacy signals in a first-in-human, phase 1 study of dual-targeting chimeric antigen receptor T cells (EGFR-IL13Rα2 CAR-T cells) in patients with recurrent glioblastoma.

Mar 4, 2024 | biorxiv.org | Yusha Sun |Xin Wang |Daniel Zhang |Zhijian Zhang

New Results Brain-wide neuronal circuit connectome of human glioblastoma Yusha Sun, Xin Wang, Daniel Y Zhang, Zhijian Zhang, Janardhan P Bhattarai, Yingqi Wang, Weifan Dong, Feng Zhang, Kristen H Park, Jamie Galanaugh, Abhijeet Sambangi, Qian Yang, Sang Hoon Kim, Garrett Wheeler, Tiago Goncalves, Qing Wang, Daniel Geschwind, Riki Kawaguchi, Huadong Wang, Fuqiang Xu, Zev A Binder, Isaac H Chen, Emily Ling-Lin Pai, Sara Stone, MacLean Nasrallah, Kimberly M Christian, Marc Fuccillo, Donald M...