Yuxi He

Sep 13, 2024 | biorxiv.org | Haoran Wu |Yuxi He |Huiqiao Chen |Weiyue Sun

AbstractObjective: We investigated the role of the RNA-binding protein G3BP1 in regulating endothelial permeability. Approach and Results: We examined the effects of loss of G3bp1 in conditional knockout mice and primary human HUVEC cells. We analyzed endothelial barrier integrity and permeability, focusing on AJ and TJ expression, under both normal and LPS-induced inflammatory conditions.

Mar 1, 2024 | onlinelibrary.wiley.com | Chao Chen |Yuxi He |Ying Ni |Zhuhai Branch

1 INTRODUCTION Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide and is closely related to type 2 diabetes.1 20%–30% of patients with NAFLD progress to non-alcoholic steatohepatitis (NASH).2 In early 2020, an international panel of experts led a consensus-driven process to develop a more appropriate terminology for NAFLD.