Yuxuan Liu

2 months ago | mdpi.com | Ziqian Yang |Hongbin Nie |Yuxuan Liu |Chunjiang Bian

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Nov 6, 2024 | digitalcommons.library.tmc.edu | Yuxuan Liu |Lihu Gong |Mingyi Chen |Junhua Lyu

Mutations in IDH genes occur frequently in acute myeloid leukemia (AML) and other human cancers to generate the oncometabolite R-2HG. Allosteric inhibition of mutant IDH suppresses R-2HG production in a subset of patients with AML; however, acquired resistance emerges as a new challenge, and the underlying mechanisms remain incompletely understood. Here we establish isogenic leukemia cells containing common IDH oncogenic mutations by CRISPR base editing.

Jul 10, 2024 | mdpi.com | Yuxuan Liu

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Nov 20, 2023 | link.aps.org | Qian Chen |Yuxuan Liu |Yu Tian

In this work, we investigate the real-time dynamics of quenching a state from phase separation in a holographic model of first-order phase transition. In addition to the typical phase-separated and high-energy final states, we have discovered a novel dynamical process that drives the system to a low-temperature supercooled final state within a narrow range of quench parameters. The critical behavior is also revealed during the fully nonlinear dynamics.

Sep 6, 2023 | pubs.rsc.org | Yong Zou |Zhaoming Xia |You Wang |Yuxuan Liu

Regulation of Frustrated Lewis Pairs on CeO2 facilitates tandem transformation of styrene and CO2 The frustrated Lewis pair (FLP) site of (Ce, Ce)-O on CeO2(110) surface undergoes the reconstruction to form (La, Ce)-O upon La-doping.