Yuying Ding

Oct 21, 2024 | biorxiv.org | Brian Ng |Yuying Ding |Matthew Cornall |Ravinash Krishna Kumar

AbstractControllable gene circuits that respond to defined inputs are essential tools in synthetic biology. By leveraging regulatory mechanisms at either transcriptional or translational levels, synthetic responsive systems have been engineered to recognize diverse signals, such as small molecules (e.g., tetracycline) or physical stimuli (e.g., light).

Aug 18, 2024 | biorxiv.org | Ying Chen |Bo Wu |Yuying Ding |Longjian Niu

AbstractPacBio Circular Consensus Sequencing (CCS) allows us to obtain highly accurate bases and simultaneously determine the methylation states of individual molecules. However, existing CCS-based methods for 5mC detection have low accuracy (<90% on most datasets) at the single-molecule level and can produce inaccurate methylation patterns.