Zeshi Li

Feb 13, 2024 | nature.com | Mike Filius |Raman van Wee |Zeshi Li |sung kim |Martin Pabst |Dick de Ridder

AbstractProteins are the primary functional actors of the cell. While proteoform diversity is known to be highly biologically relevant, current protein analysis methods are of limited use for distinguishing proteoforms. Mass spectrometric methods, in particular, often provide only ambiguous information on post-translational modification sites, and sequences of co-existing modifications may not be resolved.

Oct 25, 2023 | nature.com | Zeshi Li

AbstractO-acetylation is a common modification of sialic acids that has been implicated in a multitude of biological and disease processes. A lack of analytical methods that can determine exact structures of sialic acid variants is a hurdle to determine roles of distinct O-acetylated sialosides.