Zhe Zhuang

Sep 26, 2024 | biorxiv.org | Woong Sub Byun |Zhe Zhuang |Jakub Chrustowicz |Zuzanna Kozicka

AbstractSmall molecules that induce protein interactions hold tremendous potential as new medicines, as probes for molecular pathways, and as tools for agriculture. Explosive growth of targeted protein degradation (TPD) drug development has spurred renewed interest in proximity-inducing molecules and especially Molecular Glue Degraders (MGDs).

Jul 25, 2024 | onlinelibrary.wiley.com | Chao Chen |Yiao Di |Zhe Zhuang |Hao Cai

1 INTRODUCTION Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal diffuse large B-cell lymphoma (DLBCL), named for the loose distribution of lymphoma cells within small to medium-sized blood vessels.1 Unlike solid tumours, IVLBCL usually does not form a solid mass.2, 3 Also due to the near-ubiquitous presence of the lymphoma cells, the clinical symptoms are highly heterogeneous. IVLBCL cells have strong and constant CD20 expression.