Zhendong Mei

Aug 12, 2024 | nature.com | Fenglei Wang |Anne-Julie Tessier |Zhendong Mei |Danielle E. Haslam |Marta Guasch-Ferré |Deirdre K Tobias | +7 more

AbstractDietary haem iron intake is linked to an increased risk of type 2 diabetes (T2D), but the underlying plasma biomarkers are not well understood. We analysed data from 204,615 participants (79% females) in three large US cohorts over up to 36 years, examining the associations between iron intake and T2D risk. We also assessed plasma metabolic biomarkers and metabolomic profiles in subsets of 37,544 (82% females) and 9,024 (84% females) participants, respectively.

Jul 18, 2023 | frontiersin.org | Jian Li |Zhendong Mei

1. IntroductionIn 2020, the five major types of gastrointestinal (GI) cancer (including esophageal, gastric, colorectal, liver, and pancreatic cancers) account for 25.8% of the global cancer incidence and 35.4% of the global cancer-related deaths (Sung et al., 2021). GI cancers are significant contributors to the global burden of cancer and pose a serious challenge to public health (Arnold et al., 2020), so finding the etiology and applying suitable preventive measures are urgent.