Zhenlin Yang

Aug 22, 2024 | science.org | Paras S. Minhas |Zhenlin Yang |David Pfau |Ryan Clarke

Editor’s summaryWind energy is a key component of the general push to power the world more sustainably. However, modern blades for use in wind turbines are assembled with epoxy resins that are resource intensive to manufacture and cannot be easily recycled. Clarke et al. report a polyester material for blade manufacture that can be derived from biomass and straightforwardly deconstructed for recycling at the end of its life by heating in methanol.

Aug 22, 2024 | science.org | Paras S. Minhas |Zhenlin Yang |David Pfau |Lance Johnson

PerspectiveNeuroscienceKynurenine pathway inhibition reverses deficits in Alzheimer’s mouse modelsLance A. Johnson and Shannon L. Macauley Authors Info & AffiliationsAbstractAlzheimer’s disease (AD) is a neurodegenerative disorder with a complex and multifactorial etiology. In addition to the aggregation of amyloid-β (Aβ) peptide and tau protein, metabolic dysfunction is often described as both a cause and consequence of AD.

Aug 22, 2024 | science.org | Paras S. Minhas |Zhenlin Yang |David Pfau |Emily Boyd

Editor’s summarySamarium diiodide is widely used as a reductant in reactions of carbonyl compounds. However, it has poor solubility and must generally be used in excess quantities. Attempts to use this reductant catalytically have been hindered by its tight binding to oxygen during reactions. Boyd et al. now report that a well-chosen acid can help cleave the samarium-oxygen bond and induce turnover with electrons provided electrochemically or by metallic zinc.

Aug 15, 2024 | science.org | Paras S. Minhas |Zhenlin Yang |David Pfau |Sarah Boon

Get full access to this articleView all available purchase options and get full access to this article. Books1Nature’s Ghosts: The World We Lost and How to Bring It Back Sophie Yeo HarperNorth, 2024. 320 pp. Information & AuthorsInformationPublished In ScienceVolume 385 | Issue 671016 August 2024CopyrightCopyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Aug 1, 2024 | science.org | Yangyang Zhu |Zuanning Yuan |Simon Dedman |Zhenlin Yang

AbstractThe human NuA4/TIP60 co-activator complex, a fusion of the yeast SWR1 and NuA4 complexes, both incorporates the histone variant H2A.Z into nucleosomes and acetylates histones H4/H2A/H2A.Z to regulate gene expression and maintain genome stability. Our cryo-electron microscopy studies show that, within the NuA4/TIP60 complex, the EP400 subunit serves as a scaffold holding the different functional modules in specific positions, creating a unique arrangement of the ARP module.