Zhi Wei

May 23, 2024 | nature.com | Zhi Wei

CASTLE, a deep learning approach, extracts interpretable discrete representations from single-cell chromatin accessibility data, enabling accurate cell type identification, effective data integration, and quantitative insights into gene regulatory mechanisms.

May 23, 2024 | nature.com | Tian Tian |Xiang Lin |Zhi Wei

AbstractSpatially resolved transcriptomics (SRT) technologies have significantly advanced biomedical research, but their data analysis remains challenging due to the discrete nature of the data and the high levels of noise, compounded by complex spatial dependencies. Here, we propose spaVAE, a dependency-aware, deep generative spatial variational autoencoder model that probabilistically characterizes count data while capturing spatial correlations.

Oct 19, 2023 | frontiersin.org | Miao Li |Zhi Wei |Tyler Hyungtaek |Debra Q. Y

IntroductionGlaucoma and cardiovascular diseases are among the top global concerns, given the increasing prevalence of these conditions and the associated burdens they impose (1, 2). Glaucoma is one of the leading causes of irreversible blindness (2), and CVD is one of the leading causes of mortality (1). Glaucoma is characterized by optic disc excavation and retinal nerve fiber layer (RNFL) thinning (3).

May 7, 2023 | musingsbyzhi.medium.com | Zhi Wei

In Part 1, we talked about the why employee engagement matters more than ever, as well as the first three elements of the GRAPES mental model ( Growth, Recognition, Agency). In this article, we'll cover the rest ( Purpose, Exemplars, Sustainability). At the end, I'll also share with you some suggestions to get you started to put what you've read into practice.

Apr 30, 2023 | musingsbyzhi.medium.com | Zhi Wei

Imagine leading a team that looks like this:All your team members care deeply about what they do. They willingly push themselves to go the extra mile. They deploy their unique individual strengths, while operating as a unit. Where one falters, another one fills in. They have fun, but play to win. In victory, they cheer and celebrate. In failure, they regroup and review, learning to do better - until the next challenge comes along. Now think about your team. Is there a gap compared to what you just read?