Zhibin Hu

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Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment - Nature Communications

Apr 7, 2024 | nature.com | Zhibin Hu |Mulong Du |Hongbing Shen

AbstractThe development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) for stratifying colorectal cancer overall survival.
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population - Nature Communications

May 26, 2023 | nature.com | Jianxin Shi |Kouya Shiraishi |Jiyeon Choi |Tzu-Yu Chen |Juncheng Dai |Rayjean J. Hung | +61 more

AbstractLung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci.

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