Zhichao Yang

1 week ago | advanced.onlinelibrary.wiley.com | Wenwei Li |Yang Liu |Ming Wei |Zhichao Yang

1 Introduction Osteoarthritis (OA) is a chronic inflammatory condition characterized by synovitis and degenerative changes in articular cartilage, with clinical manifestations including pain and functional loss.[1] In the early stages of OA, synovial tissue inflammation often precedes changes in bone and cartilage structure and is associated with disease progression.[2-4] The synovial environment in OA patients is often characterized by partial oxygen deprivation, a condition exacerbated by...