Zhifeng Huang

Jan 7, 2025 | cell.com | Lintao Song |Yushu Hou |Da Xu |Xijia Dai |Jianya Luo |Yi Liu | +18 more

Keywords FXR FGF4 bile acid homeostasis FGFR4-LRH-1 pathway cholestasis Introduction Bile acids (BAs) are vital for the digestion and absorption of lipophilic nutrients and also act as signaling molecules to regulate metabolic and energy homeostasis.1,2 Disruption in BA homeostasis or associated signaling pathways can lead to cholestasis, hepatobiliary damage, and metabolic disorders.3,4 BA homeostasis is maintained in part through negative feedback mechanisms and spatiotemporally controlled...

Oct 21, 2024 | sciencedirect.com | Lintao Song |Zhifeng Huang |Jiapeng Yang |Yi Cao

Obesity causes type 2 diabetes and metabolic disease principally through induction of insulin resistance. The risk of developing diabetes is over 3-fold in overweight individuals and more than 10-fold in obese individuals compared with lean individuals.1 Insulin resistance can rapidly develop during overnutrition even before obesity manifests, resulting in glucose intolerance, adipose tissue dysfunction, and hepatic steatosis.

Feb 26, 2024 | nature.com | Zhifeng Huang |Huiqing Zhu

AbstractThis study is nationwide multicenter epidemiological research, aimed at investigating the distribution changes and seasonal patterns of various airborne allergens among preschool children with allergic rhinitis (AR) in different regions of China, and analyzing the clinical correlation between sensitization to various airborne allergens and AR symptoms in children.