Zhihui Shao

May 6, 2024 | nature.com | Zhihui Shao

AbstractGeneral, catalytic and enantioselective construction of chiral α,α-dialkyl indoles represents an important yet challenging objective to be developed. Herein we describe a cobalt catalyzed enantioselective anti-Markovnikov alkene hydroalkylation via the remote stereocontrol for the synthesis of α,α-dialkyl indoles and other N-heterocycles. This asymmetric C(sp3)−C(sp3) coupling features high flexibility in introducing a diverse set of alkyl groups at the α-position of chiral N-heterocycles.

Apr 28, 2023 | chemistry-europe.onlinelibrary.wiley.com | Zhihui Shao |Xiaoyu Zhang |Xinyan Li |Weilin Wang

Graphical Abstract Herein, an efficient and green procedure for the synthesis of tetrahydro-β-carbolines via dehydrogenative coupling of alcohols with tryptamines is reported. The reaction was carried out under mild conditions in the presence of a catalytic amount of the iPrPNP−Mn catalyst and a weak base (Na2CO3).