Zhilin Qu

Dec 8, 2023 | link.aps.org | Zhaoyang Zhang |Yuhao Zhang |Zhilin Qu

We show that a positive feedback loop between sodium current inactivation and wave-front ramp-up speed causes a saddle-node bifurcation to result in bistable planar and spiral waves in electrically excitable media, in which both slow and fast waves are triggered by different stimulation protocols. Moreover, the two types of spiral wave conduction may interact to give rise to more complex spiral wave dynamics.

Dec 1, 2023 | jacc.org | Zhaoyang Zhang |Pedro Brugada |James Weiss |Zhilin Qu

References1. "Brugada syndrome: a decade of progress". Circ Res . 2002;91:1114-1118. 2. "Pathogenesis and management of Brugada syndrome". Nat Rev Cardiol . 2016;13:744-756. 3. "Present status of Brugada syndrome". J Am Coll Cardiol . 2018;72:1046-1059. 4. "The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization". J Mol Cell Cardiol . 2010;49:543-553. 5. "Repolarization versus depolarization defects in Brugada syndrome". J Am Conll Cardiol EP . 2017;3:364-366. 6.