Zhiqiang Yan

Jan 3, 2025 | nature.com | Zhiqiang Yan

AbstractLipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance (ABC) effect. We design three ionizable oligomers (IOs) that, with polylactide-polyethylene glycol (PLA-PEG), form a potential siRNA delivery system, named Ionizable Polymeric Micelles (IPMs). The siRNA encapsulated IPMs escape from lysosomes upon cellular uptake, and silence the target gene.

Feb 6, 2024 | onlinelibrary.wiley.com | Zhiqiang Yan |Luming Wu |Jingwen Huang |Fenghui Lu

CONFLICT OF INTEREST The authors declare no competing financial interest. REFERENCES , , , , & (2007) Stability and dynamical behavior in a lake-model and implications for regime shifts in real lakes. Ecological Modelling, 206(1-2), 54–62. Available from: https://doi.org/10.1016/j.ecolmodel.2007.03.019 , , & (2022) Phosphorus mining from eutrophic marine environment towards a blue economy: the role of bio-based applications. Water Research, 219, 118505.

Jan 16, 2024 | nature.com | Zhiqiang Yan |Jin Wang

AbstractThe elegant design of protein sequence/structure/function relationships arises from the interaction patterns between amino acid positions. A central question is how evolutionary forces shape the interaction patterns that encode long-range epistasis and binding specificity. Here, we combined family-wide evolutionary analysis of natural homologous sequences and structure-oriented evolution simulation for two-component signaling (TCS) system.