Zhiqing Zhang

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Articles

Integrating L-Cys-AuNCs in ZIF-8 with Enhanced Fluorescence and Strengthened Stability for Sensitive Detection of Copper Ions

Dec 20, 2024 | mdpi.com | Zhiqing Zhang

1. IntroductionGold nanoclusters (AuNCs), which consist of atoms, have achieved considerable attention in sensing, catalysis, diagnostic, and therapeutic applications due to their customizable structures and significant physical and chemical characteristics [1,2,3,4]. Ligands play a significant role in stabilizing and regulating the properties of AuNCs [2,5,6].
Stoichiometry of HIV-1 Envelope Glycoprotein Protomers with Changes That Stabilize or Destabilize the Pretriggered Conformation

Oct 27, 2024 | biorxiv.org | Zhiqing Zhang |Saumya Anang |Qian Wang |Hanh Nguyen

AbstractDuring human immunodeficiency virus (HIV-1) entry into host cells, binding to the receptors, CD4 and CCR5/CXCR4, triggers conformational changes in the metastable envelope glycoprotein (Env) trimer ((gp120-gp41)3). CD4 binding induces Env to make transitions from its pretriggered conformation (PTC) to more "open" conformations that are sensitive to inhibition by antibodies, CD4-mimetic compounds (CD4mcs) and exposure to cold.

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