Zhong-Liang Wang

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Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2 - Nature Communications

Aug 28, 2024 | nature.com | Zhong-Liang Wang |Lily Wang |Shu-Yi Lin |Lu-Hai Wang |Hui-Chun Cheng

AbstractMost cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation to aerobic glycolysis for energy production. By reducing enzyme activity of pyruvate kinase M2 (PKM2), cancer cells attain a greater fraction of glycolytic metabolites for macromolecule synthesis needed for rapid proliferation.

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