Zihong Chen

Mar 5, 2024 | nature.com | Yihui Shen |Zihong Chen |Tianxia Xiao |Catherine M Call |Yasuo Yoshikuni |Huimin Zhao | +3 more

AbstractMetabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms, from yeast to mammals, derive usable energy primarily through glycolysis and respiration. Although respiration is more energy efficient, some cells favor glycolysis even when oxygen is available (aerobic glycolysis, Warburg effect). A leading explanation is that glycolysis is more efficient in terms of ATP production per unit mass of protein (that is, faster).