Yasuo Yoshikuni

Oct 20, 2024 | nature.com | Jerome Johnson |Yasuo Yoshikuni |Christopher Francis |Soichi Wakatsuki

AbstractThe 3-hydroxypropionate/4-hydroxybutyrate (3HP/4HB) cycle from ammonia-oxidizing Thaumarchaeota is currently considered the most energy-efficient aerobic carbon fixation pathway. The Nitrosopumilus maritimus 4-hydroxybutyryl-CoA synthetase (ADP-forming; Nmar_0206) represents one of several enzymes from this cycle that exhibit increased efficiency over crenarchaeal counterparts.

Jul 20, 2024 | nature.com | Yasuo Yoshikuni |Tobias J Erb |Ramon Gonzalez |Karolina Michalska |Natalia Maltseva |Philipp Wichmann | +1 more

Abstract2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, condenses formyl-CoA with aldehydes or ketones. The one-carbon elongation biochemistry based on HACL/S has enabled the use of molecules derived from greenhouse gases as biomanufacturing feedstocks.

Jul 2, 2024 | analyticalsciencejournals.onlinelibrary.wiley.com | Patrick A. Sanford |Ian K. Blaby |Yasuo Yoshikuni |Benjamin M. Woolston

Acetogenic Clostridia are anaerobic bacteria of increasing academic and industrial interest thanks to their unique ability to metabolize single carbon substrates at high energetic efficiency, giving them significant potential in the development of the circular bioeconomy and to combat climate change (Bar-Even et al., 2012; Schuchmann & Müller, 2014).

Mar 5, 2024 | nature.com | Yihui Shen |Zihong Chen |Tianxia Xiao |Catherine M Call |Yasuo Yoshikuni |Huimin Zhao | +3 more

AbstractMetabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms, from yeast to mammals, derive usable energy primarily through glycolysis and respiration. Although respiration is more energy efficient, some cells favor glycolysis even when oxygen is available (aerobic glycolysis, Warburg effect). A leading explanation is that glycolysis is more efficient in terms of ATP production per unit mass of protein (that is, faster).

Jul 15, 2023 | biorxiv.org | J Johnson |Yasuo Yoshikuni |Bradley B. Tolar |Bilge Tosun

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