Zijian Zhang

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Articles

Macroevolutionary divergence of gene expression driven by selection on protein abundance

1 month ago | science.org | Jesús Aguirre-Gutiérrez |Jennifer Hill |Zijian Zhang |

Editor’s summaryProteins are translated from messenger RNA (mRNA), and the levels of these biomolecules are often correlated for a given gene. However, this observation is at odds with the fact that many variants that alter gene expression do not alter protein levels. Cope et al. tested several phylogenetic models relating mRNA and protein levels in coupled transcriptomic and proteomic data from skin samples across 10 mammals.
In Science Journals

1 month ago | science.org | Jesús Aguirre-Gutiérrez |Jennifer Hill |Zijian Zhang |Leslie K. Ferrarelli

Neuroinflammation Acetylation to fuel neuroinflammationLeslie K. FerrarelliFluorescence microscopy image of mouse hippocampus area CA3 reveals localization of GCN5 (red) in microglia, but not astrocytes (green). Open in viewerThe acetyltransferase GCN5 promotes inflammation in peripheral tissues. Cho et al. found that GCN5 mediates inflammation in the brain as well, suggesting that it may be a target for treating neuroinflammatory diseases.
In Other Journals

1 month ago | science.org | Jesús Aguirre-Gutiérrez |Jennifer Hill |Zijian Zhang |Sacha Vignieri

Conservation A patchwork won’t workSacha VignieriHuman activity adjacent to protected areas like the Central Suriname Nature Preserve still has negative effects on sensitive species within. PHOTO: ARIADNE VAN ZANDBERGEN/ALAMY STOCK PHOTOOpen in viewerContinued human population growth has led to biodiversity loss. Our response to this problem has been to establish specific protected areas.
Multi-TACs: Targeting Solid Tumors with Multiple Immune Cell Co-engagers

Jan 9, 2025 | dx.doi.org | Yuxuan Zhang |Zijian Zhang |Feng Lin
Deep Vein Thrombosis After Laparoscopic Nephrectomy: A Case Report

Jul 18, 2024 | preprints.org | Zijian Zhang

PreprintCase ReportVersion 1This version is not peer-reviewedVersion 1: Received: 16 July 2024 / Approved: 18 July 2024 / Online: 18 July 2024 (17:22:58 CEST)Zhang, Z. Deep Vein Thrombosis After Laparoscopic Nephrectomy: A Case Report. Preprints 2024, 2024071544. https://doi.org/10.20944/preprints202407.1544.v1Zhang, Z. Deep Vein Thrombosis After Laparoscopic Nephrectomy: A Case Report. Preprints 2024, 2024071544.
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis - Cell Death & Disease

Mar 22, 2024 | nature.com | Zijian Zhang |Zifeng Wang

AbstractAURKA is an established target for cancer therapy; however, the efficacy of its inhibitors in clinical trials is hindered by differential response rates across different tumor subtypes. In this study, we demonstrate AURKA regulates amino acid synthesis, rendering it a vulnerable target in KEAP1-deficient non-small cell lung cancer (NSCLC). Through CRISPR metabolic screens, we identified that KEAP1-knockdown cells showed the highest sensitivity to the AURKA inhibitor MLN8237.
Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation - Genes & Immunity

Jan 21, 2024 | nature.com | Zijian Zhang

AbstractInterferon-γ (IFN-γ) is an important cytokine in tissue homeostasis and immune response, while studies about it in antibody-mediated rejection (ABMR) are very limited. This study aims to comprehensively elucidate the role of IFN-γ in ABMR after renal transplantation.
Quantitative evaluation of asphalt blending characteristics in epoxy‐modified hot recycled asphalt mixtures based on 3D confocal fluorescence technology

Dec 28, 2023 | onlinelibrary.wiley.com | Lei Zhang |Long Cheng |Qing Lu |Zijian Zhang

CONFLICT OF INTEREST STATEMENT The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES 1, , , Constr. Build. Mater. 2019, 211, 453. 2, , , J. Cleaner Prod. 2017, 156, 911. 3, , , , , , , , , , J. Traffic Transp. Eng. (Engl. Ed.) 2021, 8, 815. 4, , , , Int. J. Pavement Res. Technol. 2023, 1, 1. 5, , , Int. J. Pavement Res. Technol. 2023, 1, 1. 6, , , Mater. Struct.
Rational design of a glycopeptide probe system based on a reconfigurable immune microenvironment

Jun 28, 2023 | pubs.rsc.org | Xin Wang |Yao Yu |Limin Zhang |Zijian Zhang

Rational design of a glycopeptide probe system based on a reconfigurable immune microenvironment† Xin Wang, a Yao Yu, a Limin Zhang, a Zijian Zhang,a Shixiang Lu *a and Weizhi Wang *a Abstract Glioma is a highly challenging human malignancy and conventional drugs typically exhibit low blood–brain barrier (BBB) permeability as well as poor tumor targeting.
A Multi-Dimensional Covert Transaction Recognition Scheme for Blockchain

Feb 16, 2023 | mdpi.com | Zijian Zhang |Shuqi Wang |Zhen Li |Feng Gao

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Zijian Zhang

Articles

Macroevolutionary divergence of gene expression driven by selection on protein abundance

In Science Journals

In Other Journals

Multi-TACs: Targeting Solid Tumors with Multiple Immune Cell Co-engagers

Deep Vein Thrombosis After Laparoscopic Nephrectomy: A Case Report

AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis - Cell Death & Disease

Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation - Genes & Immunity

Quantitative evaluation of asphalt blending characteristics in epoxy‐modified hot recycled asphalt mixtures based on 3D confocal fluorescence technology

Rational design of a glycopeptide probe system based on a reconfigurable immune microenvironment

A Multi-Dimensional Covert Transaction Recognition Scheme for Blockchain

Contact details

Emails

Socials & Sites