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Researchers discover a new metabolic compound that regulates body weight

Nov 12, 2024 | bcm.edu | Taylor Barnes

Researchers at Baylor College of Medicine, Stanford University School of Medicine and collaborating institutions report in the journal Cell the discovery of BHB-Phe, a novel compound produced by the body that regulates appetite and body weight through interactions with neurons in the brain. Until now, BHB has been known as a compound produced by the liver to be used as fuel.
How estrogen's millisecond-fast action happens

Oct 2, 2024 | bcm.edu | Taylor Barnes

Estrogen, the major female ovarian hormone, can trigger nerve impulses within milliseconds to regulate a variety of physiological processes. At Baylor College of Medicine, Louisiana State University and collaborating institutions, researchers discovered that estrogen’s fast actions are mediated by the coupling of the estrogen receptor-alpha (ER-alpha) with an ion channel protein called Clic1.
Dan L Duncan Comprehensive Cancer Center launches Phase 1 Clinical Trial Program | BCM

Aug 19, 2024 | bcm.edu | Molly Chiu

Baylor College of Medicine’s Dan L Duncan Comprehensive Cancer Center has launched the Albert and Margaret Alkek Foundation Center for Experimental Therapeutics,...
Serotonin 2C receptor regulates memory in mice and humans - implications for Alzheimer's disease

Jun 28, 2024 | bcm.edu | Taylor Barnes

Researchers at Baylor College of Medicine, the University of Cambridge in the U.K. and collaborating institutions have shown that serotonin 2C receptor in the brain regulates memory in people and animal models. The findings, published in the journal Science Advances, not only provide new insights into the factors involved in healthy memory but also in conditions associated with memory loss, like Alzheimer’s disease, and suggest novel avenues for treatment.
CAR T cell therapy for pediatric brain cancer warrants further study | BCM

May 22, 2024 | bcm.edu | Molly Chiu

Novel therapeutic approaches are needed for children with diffuse midline glioma (DMG) and other recurrent high-grade central nervous system (CNS) tumors,...
First step to untangle DNA: supercoiled DNA captures gyrase like a lasso ropes cattle

Apr 11, 2024 | bcm.edu | Taylor Barnes

Picture in your mind a traditional “landline” telephone with a coiled cord connecting the handset to the phone. The coiled telephone cord and the DNA double helix that stores the genetic material in every cell in the body have one thing in common; they both supercoil, or coil about themselves, and tangle in ways that can be difficult to undo. In the case of DNA, if this overwinding is not dealt with, essential processes such as copying DNA and cell division grind to a halt.
New guidelines uphold lifelong competency of surgeons

Apr 9, 2024 | bcm.edu | Taylor Barnes

As millions of Americans approach age 66, they face the inevitable question, is it time to retire? The physician population is aging alongside the general population – more than 40% of physicians in the U.S. will be 65 years or older within the next decade. In the case of surgeons, there is little guidance on how to best ensure their competency throughout their career and at the same time maintain patient safety while preserving physician dignity.
Baylor College of Medicine wins the 2024 STAT Madness Science Competition

Apr 5, 2024 | bcm.edu | Taylor Barnes

Content This year, the College was represented by work conducted by Drs. Anthony Maresso, Sara Javornik Cregeen, Michael Tisza, Joseph Petrosino and colleagues, which is published in Nature Communications.
Novel combination therapy offers promising results for treatment-refractory hepatoblastoma

Feb 21, 2024 | bcm.edu | Taylor Barnes

Hepatoblastoma (HB) is the most common liver cancer in children. Researchers and physicians in the field are concerned because in the last decade HB has been rising rapidly worldwide and has seen the most rapid increase among all pediatric solid tumors. A team led by researchers at Baylor College of Medicine has been working on improving therapies for this devastating disease. They recently reported in the a novel treatment strategy that produced encouraging results in animal models.
New Year's resolutions: Why do we give up on them so quickly? | BCM

Jan 11, 2024 | bcm.edu | Taylor Barnes

One week into the new year, and many have already given up on their well-intentioned New Year’s resolutions. While the reasons to say farewell to these...