Bioprocess Online

Bioprocess Online serves as the top resource for technical insights, industry expertise, and valuable content tailored for the biotherapeutic community. Whether you are a bioprocess engineer, scientist, bioprocessing manager, biotechnology producer, consultant, QA/QC professional, project manager, director, purchaser, marketer, or work within biopharmaceutical supply chain or facility management, you can tap into a robust online community that offers the latest business and scientific developments essential for your success. Covering everything from upstream to downstream processing, bioanalysis, and biomanufacturing, our mission is to equip readers with the most current information on the topics, challenges, and news that matter most to them.

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Analytics And Cross-Functional Communication: Keys To Purifying Complex Molecules

1 week ago | bioprocessonline.com | Tyler Menichiello

By Tyler Menichiello, contributing editor In case you missed it, this month’s Bioprocess Online Live was all about the challenges and special considerations for purifying multispecifics — molecules engineered to engage two or more distinct targets (e.g., bispecific or trispecific antibodies). I was joined by two expert panelists: Mark Fitchmun, president and CEO of Somatek, and Jian Ren, Ph.D., a principal scientist in AbbVie’s manufacturing science and technology (MSAT) bioresearch center.
An Extended Kinetics Study Of AAV Viral Vector Production

1 week ago | bioprocessonline.com | Lucia Fernandez |Lucia Fernández |Dan Brownell |Junwei Sun

By Lucia Fernandez, Ph.D., Dan Brownell, and Junwei Sun VintaBio employs a proprietary HEK293 clone, VintaCell™, optimized for growth in fixed-bed bioreactors, alongside a chemically defined transfection reagent, VintaFect™, to support scalable and cost-effective AAV vector production. These components are integrated into VintaProcess™, a unique manufacturing platform that uses a proprietary perfusion system with media recirculation to enhance vector yield and consistency.
05.29.25 -- Lean Thinking For Pharma - Flow Without Facility Upheaval

1 week ago | bioprocessonline.com | Irwin Hirsh |Q-Specialists AB |Tyler Menichiello |Eric Hennessy

FOCUS ON FACILITIES DESIGN & MAINTENANCELean offers manufacturers a host of efficiencies, but they don't all work for GMP. Here are some ideas for translating best practices for a highly-regulated industry. How Modular Facility Design Can Accelerate GMP Facility ConstructionAutolus Therapeutics' COO talks about the accelerated construction of the company's cell therapy manufacturing facility, The Nucleus.
How Modular Facility Design Can Accelerate GMP Facility Construction

2 weeks ago | bioprocessonline.com | Tyler Menichiello

By Tyler Menichiello, contributing editor How does that famous Shakespeare quote go? “To build a brick-and-mortar facility or find a manufacturing partner, that is the question.” Okay, Hamlet may not have been fretting over his company’s manufacturing strategy, but it’s a decision that weighs on most biotech executives’ minds at some point. In my time interviewing industry decision-makers, I’ve heard strong arguments for both.
05.20.25 -- April 2025 - CDMO Opportunities And Threats Report

2 weeks ago | bioprocessonline.com | Junwei Sun |Lucia Fernandez |Lucia Fernández |Matthew Ercolino |Jonathan Rocher

Take a tour of Nanoform's best-in-class nanodevelopment capabilities, setting new standards in innovation. Their highly specialized team excels in creating unique nanoparticles for both small and large molecule APIs. With 14 development lines for small molecules and 5 for large molecules, Nanoform offers unmatched scalability and precision. Leveraging cutting-edge technology, they produce nanoformed materials as small as 10 nanometers.
05.20.25 -- Business Of Biotech Newsletter

2 weeks ago | bioprocessonline.com | Ben Comer |Shetal Vyas |Denise N. Bronner |David W. Stowe

In the business of Uniquity Bio, Insmed, Chinese biotech and investment trends. Who — and what — is a life science leader in 2025? In the first month of my tenure as host of the Business of Biotech, it’s clearer to me than ever that leading in life sciences requires a constellation of expertise: strong leaders in drug development, in finance and operations, in policy and commercialization, and elsewhere. A broadening set of calculations is needed, to take and manage the risks required to succeed.
05.07.25 -- From BPI West: A Roundtable Discussion On Continuous Manufacturing

1 month ago | bioprocessonline.com | Tyler Menichiello |Lauren Parker |Jeffrey Cassel |Mike McManaway

FOCUS ON DOWNSTREAM MANUFACTURINGProcess development experts share their thoughts on continuous manufacturing at this year's BPI West, touching on its benefits and present barriers to adoption. Process Intensification Of Monoclonal Antibody Purification ProcessWatch to explore an intensified mAb purification process that utilizes leading purification technologies, highlighting intensified capture, polishing, and drug delivery.
05.05.25 -- Process Optimization Or Full-Scale Automation?

1 month ago | bioprocessonline.com | Tyler Menichiello |Ruth Rowland-Jones |Julia Hupfeld |Alison Rees-Manley

FOCUS ON UPSTREAM MANUFACTURINGWhile continuous processing often steals the spotlight with its promise of uninterrupted workflows, many seasoned professionals continue to advocate for process optimization and intensification as equally effective—and far less capital-intensive—alternatives. From BPI West: An Upstream Scientist's Advice On Target GlycosylationBioprocess Online spoke to an upstream scientist at Bristol Myers Squibb during this year's BPI West. Here's what he had to say.
A Facilities Expert Answers Audience Questions On Construction And Validation

1 month ago | bioprocessonline.com | Tyler Menichiello

By Tyler Menichiello, contributing editor If you missed April’s Pharmaceutical Online Live event on facility design and validation, don’t worry — you can watch the entire recording or check out my summary of key takeaways here. It was an engaging hour of discussion on everything from single-use systems to modular facility design and more. Unfortunately, we didn’t have enough time to answer every question that came through from our audience.
04.29.25 -- Navigating Tariffs: Implications And Strategies For Pharmaceuticals Manufacturers

1 month ago | bioprocessonline.com | Nero Haralalka |Junwei Sun |Lucia Fernandez |Lucia Fernández |Matthew Ercolino

Multispecific molecules bring added complexity to downstream purification—think incorrect chain pairings, aggregation, fragmentation, and lower yields. Join Bioprocess Online Live as we explore how developers are addressing these challenges to achieve high purity and efficient processes. Gain insights into key considerations for downstream teams when designing purification strategies for these advanced biologics. Registration is free thanks to the support of Thermo Fisher Scientific.