Journal of Biomedical Optics

Aug 20, 2024 | spiedigitallibrary.org | Marien Ochoa |Arthur Petusseau |Matthew Reed |Brian Pogue

1. IntroductionUnderstanding tissue oxygen content, especially the lack of oxygen, is key for assessing proper tissue function. Of special interest are tumors, which often grow with chaotic neo-vasculature, subsequently creating both chronic and transient hypoxia conditions.

Jun 14, 2024 | spiedigitallibrary.org | Christopher Hansen |Jaidip Jagtap |Abdul K. Parchur |Gayatri Sharma

1. IntroductionOften described as the “forgotten system,”1 the lymphatic system is necessary for maintaining homeostasis and immune function.

Mar 8, 2024 | spiedigitallibrary.org | Jason SMith |Jason Smith |Booz Allen Hamilton |Chao Liu |Jeannine Degnan

1. IntroductionDrug development is currently arduous and costly.1,2 Therefore, rapid, cost-effective evaluation of drug candidates in translationally relevant in vitro model systems is highly desirable. Concurrently, tumor and patient heterogeneity present a difficult barrier to accurate drug efficacy determination. For this, patient-specific assays are currently under development. In vitro models with increasing translational relevance include spheroids, organoids, and excised primary tumor tissue.

Sep 22, 2023 | spiedigitallibrary.org | Yingming Lai |Miguel Marquez |Jinyang Liang

1. IntroductionOptical imaging of transient events in their actual time of occurrence exerts compelling scientific significance and practical merits.1 Occurring in two-dimensional (2D) space and at femtosecond (1fs=10−15s) to microsecond (1μs=10−6s) time scales, these transient events reflect many important fundamental mechanisms in biology.2–4 However, many transient phenomena are either nonrepeatable or difficult to reproduce.

Aug 30, 2023 | spiedigitallibrary.org | Robert Wilson |Rebecca Rowland |Gordon Kennedy |Chris Campbell

1. IntroductionIncorporating emerging technologies into the clinical workflow for the early staging of burn severity may provide a crucial inroad toward improved diagnostic accuracy and personalized treatment.1 Early knowledge of the severity of the burn gives the clinician the ability to discuss treatment options and prognostication for hospital stays, healing, and scarring.