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Longitudinal Data Links CKM to Cognitive Decline

2 weeks ago | medcentral.com | Racheal Ede

Individuals with higher risk for cardiovascular‐kidney‐metabolic (CKM) syndrome also had a greater risk of cognitive decline, based on data from a 20‐year longitudinal study published in the Journal of the American Heart Association this month. Cardiovascular‐kidney‐metabolic (CKM) syndrome, a newly defined condition highlighting the interactions between chronic kidney disease, metabolic risk factors, and cardiovascular disease, is on the rise globally.
Investigational IPF Therapy Developed Using AI

2 weeks ago | medcentral.com | Aaron Tallent

Idiopathic pulmonary fibrosis (IPF) is a challenging respiratory condition with limited treatment options. However, new therapies are being investigated, including one that was developed in part through generative artificial intelligence (AI). Research findings on rentosertib (INS018-055) were presented this week at the 2025 American Thoracic Society (ATS) annual meeting in San Franciso.
New Criteria Pin Down Difficult-to-Manage Axial Spondyloarthritis

2 weeks ago | medcentral.com | Heidi Splete

A substantial number of patients with axial spondyloarthritis (axSpA) do not achieve remission or respond to treatment despite available therapies, but a new definition offers guidance to improve clinical care.
Lifestyle Assessments Hit EHRs

2 weeks ago | medcentral.com | Angie Drakulich

The American College of Lifestyle Medicine (ACLM) and software company Epic Systems have released the first set of integrated lifestyle medicine assessment tools for use in electronic health records. ACLM was inducted into the American Medical Association House of Delegates in 2024. Here, David Michael, MD, DipABLM, medical director of the Lifestyle Medicine Clinic at ECU Health in Greenville, NC, provides details on what the new assessments provide and why medical practices may need them.
Topol on Extending Lifespan, Starting with Disease Prevention

2 weeks ago | medcentral.com | Eric J. Topol |Ivan Oransky

In this timely interview, Eric Topol, MD, discusses with Ivan Oransky, MD, key clinical takeaways from his new book, Super Agers: An Evidence-Based Approach to Longevity, published this month by Simon & Schuster. On the docket: what physicians can do now to help prevent the top three age-related diseases – cardiovascular disease, cancer, and neurodegenerative disease – in their patients, the overlooked role of the immune system, and why GLP-1s are outperforming all expectations.
Can you identify a potential thyroid emergency?

2 weeks ago | medcentral.com | Heidi Splete

Thyroid storm is a life-threatening, emergent condition that develops from untreated or undertreated hyperthyroidism or overactive thyroid (thyrotoxicosis). A diagnosis of thyroid storm needs clinical suspicion, and clinicians should not wait for results of lab tests before starting treatment, wrote Binod Pokhrel, MD, of the University of Health Sciences, Lahore, Pakistan, and colleagues in a summary of thyroid storm in StatPearls.
Subclinical Hypothyroidism Differs by Sex, Age, and Race

2 weeks ago | medcentral.com | Oladimeji Ewumi

Subclinical hypothyroidism may be overdiagnosed due to reference ranges not adjusted for factors such as race, sex, and age, according to new data. Published in the Annals of Internal Medicine, the study is the first to use large national datasets to show how individual-level reference intervals impact thyroid disease prevalence estimates.
Bacterial Toxins Linked to Early-Onset Colorectal Cancer

3 weeks ago | medcentral.com | Racheal Ede

Exposure to colibactin bacteria in early childhood was associated with early-onset colorectal cancer (EOCRC) as colibactin-induced mutations were 3.3 times more prevalent in individuals diagnosed before age 40, compared to those above 70, according to a global study. The growing incidence of early-onset colorectal cancer over the past two decades has raised significant questions about its underlying causes and specific risk factors.
Trump Issues 30-Day Deadline for Drug Companies to Lower Prices

3 weeks ago | medcentral.com | Marcia Frellick

President Donald Trump on Monday signed an executive order that sets a 30-day deadline for drug manufacturers to lower their costs for prescription drugs in the United States or face new caps on what the government will pay, according to the Associated Press. The proposal is what he calls a “most favored nation” pricing model. Under the order, the US Department of Health and Human Services (HHS), led by Robert F. Kennedy, Jr., would negotiate new prices for drugs over the next month.
New Toxicity Syndrome Identified in Patients with Autoimmune Disease

3 weeks ago | medcentral.com | Heidi Splete

A new form of toxicity has been identified in patients with autoimmune diseases receiving CD19-targeting CAR T-cell therapy, according to data from an observational study of 39 individuals. CD19-targeting chimeric antigen receptor (CAR) T-cell therapy is a relatively new treatment for severe forms of systemic lupus erythematosus (SLE), idiopathic inflammatory myopathy, and systemic sclerosis, although it has a history of use in patients with cancer.