Oncology Nurse Advisor

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XPO1 Inhibition With Selinexor Promising in R/R AML in Pediatric Patients

5 days ago | oncologynurseadvisor.com | Jennifer Larson

The selective exportin 1 (XPO1) inhibitor selinexor (KPT-330) showed promise in improving survival rates among pediatric patients with relapsed or refractory (R/R) leukemia in a phase 1/2 study at St. Jude Children’s Research Hospital in Memphis, Tennessee (SELHEM; NCT02212561). These findings were presented by Katelyn (Purvis) Daniels, MD, at the 2025 ASPHO Conference in Louisville, Kentucky.
Patient-Prioritized Outcomes Better After Radical Cystectomy vs Bladder Sparing Tx for NMIBC

1 week ago | oncologynurseadvisor.com | John Schieszer

The CISTO study assessed patient-important outcomes after radical cystectomy (RC) and bladder-sparing therapy (BST), both standard of care treatment options for recurrent high-grade non-muscle invasive bladder cancer (NMIBC). Surprisingly, patient-prioritized outcomes were similar or better among patients choosing RC rather than BST, an investigator reported at a late-breaking session at the American Urological Association 2025 meeting in Las Vegas, Nevada.
ASPHO 2025: Age-Specific Differences in Angiosarcoma Explored in Pediatric, Adult Patients

2 weeks ago | oncologynurseadvisor.com | Jennifer Larson

Malignant vascular tumors, such as angiosarcoma, are rare among children, but pediatric patients who develop these tumors may benefit from more aggressive therapies than adults, according to a paper presented by Federico Moral Ortega, MD, of the University of Miami Sylvester Comprehensive Cancer Center in Miami, Florida, at the 2025 APSHO Conference in Louisville, Kentucky.
Symptom Science, Omics-Based Biomarkers, and Precision Medicine

2 weeks ago | oncologynurseadvisor.com | Jessica Nye

A systematic review defined biomarkers used in precision medicine. The review was published in Seminars in Oncology Nursing. Symptom science is a nurse-led field focused on identifying, managing, and predicting patient symptoms. Precision medicine is focused on person-focused approaches to health care, focusing on the interaction between the genome, lifestyle, and the environment.
Possible Link Identified Between PBC and Diffuse Large B-Cell Lymphoma

2 weeks ago | oncologynurseadvisor.com | Ozge Ozkaya

There is a strong association between primary biliary cholangitis (PBC) and lymphoma, such as diffuse large B-cell lymphoma (DLBCL), according to a case study and literature review published in the scientific journal Cureus. The study also showed that the presence of lymphoma can worsen liver damage in PBC and significantly accelerate the progression of liver disease. “Studies have shown that a variety of autoimmune diseases . . .
Psychological Stress Biomarker Levels Found Higher in Neuro-Oncology Caregivers

2 weeks ago | oncologynurseadvisor.com | Ryner Lai

C-reactive protein (CRP) levels are found to be increased among caregivers of persons with a primary malignant brain tumor, highlighting the role of this biomarker as an indicator of psychological stress, according to a study published in Cancer Nursing. A diagnosis of a primary malignant brain tumor has immediately detrimental effects on a patient’s quality of life and outlook, with treatment often limiting personal independence.
A History of Cannabis-Use Disorder Increases Risk of Mortality in Colon Cancer

3 weeks ago | oncologynurseadvisor.com | Ryner Lai

Patients with colon cancer who have a history of cannabis-use disorder (CUD) are at an increased risk of mortality, according to a study published in Annals of Epidemiology. Cannabis use has increasingly become a topic of popular discourse, with deeper social acceptance. However, unlike recreational use, patients with CUD have a harmful pattern of cannabis use that may result in psychiatric and physical complications.
Few Pediatric Oncology Patients Receive Pathway-Consistent Symptom Care

3 weeks ago | oncologynurseadvisor.com | Jessica Nye

Few pediatric patients received care pathway- or clinical practice guideline (CPG)-consistent symptom care at 10 cancer treatment sites with symptom management care pathway policies. These findings were published in JCO Oncology Practice. Toxic symptoms are rarely documented or treated in the pediatric oncology setting. Investigators from The Hospital for Sick Children in Canada conducted this secondary analysis of data from a cluster randomized controlled trial (NCT04614662).
Niraparib-Bevacizumab Maintenance Deemed Promising for Recurrent Ovarian Cancer

1 month ago | oncologynurseadvisor.com | Vicki Moore

Maintenance with niraparib and bevacizumab can be effective in patients with platinum-sensitive, recurrent ovarian cancer previously treated with a PARP inhibitor, according to research presented at the SGO 2025 Annual Meeting on Women’s Cancer.
Pharmacist-Led Clinic for Administering Venetoclax Safe, Effective for CLL

1 month ago | oncologynurseadvisor.com | Vicki Moore

Use of a pharmacist-led clinic for administering venetoclax was considered safe and effective in a study including patients with chronic lymphocytic leukemia (CLL) that was led by a research team based in Edmonton, Alberta, Canada. Findings were reported in the Journal of Oncology Pharmacy Practice. The pharmacist-led clinic was implemented in October 2020 to provide ramp-up of venetoclax at a tertiary care center in patients considered to have a low or moderate risk of tumor lysis syndrome (TLS).