The Analytical Scientist

This initial editorial outlines the goals and aspirations of the publication and its website.

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Articles

The Analytical Scientist | Riva Returns!

2 weeks ago | theanalyticalscientist.com | Frank van Geel |James Strachan

After a pandemic-induced pause, Riva del Garda (Italy) will once again play host to the (44th) International Symposium on Capillary Chromatography and the (21st) GC×GC Symposia, on May 17–22, 2026. Long-time leader of the event Luigi Mondello shares the driving forces behind the relaunch: a surge in chromatographic innovation, a need for in-person exchange, and a global community eager to reconnect – especially at Riva del Garda. Why have you decided to restart the Riva conference?
Gary Patti: Metabolomics Is Not in Crisis

2 weeks ago | theanalyticalscientist.com | James Strachan

The debate over the role of in-source fragmentation (ISF) in untargeted metabolomics continues.
Dark Metabolome Debate: A Call for Context

2 weeks ago | theanalyticalscientist.com | James Strachan

Following The Analytical Scientist’s interviews with Pieter Dorrestein and Yasin El Abiead, and responses from Martin Giera and Gary Siuzdak, Shuzhao Li offers a clarifying perspective on the role of in-source fragmentation in untargeted metabolomics. For Li – whose recent preprint surveys LC-MS data from human plasma and serum – the real story is less about conflict and more about context.
The Optical Imaging Platform Inspired by Butterfly Wings

3 weeks ago | theanalyticalscientist.com | Jessica Allerton

Scientists have been looking for the key to improved cancer diagnostics since its conception, but have we been searching in the wrong places? Researchers at the University of California San Diego have found success in taking inspiration from butterfly wings. Using the microscopic structures found on Morpho butterfly wings, the team have developed a simple and cost effective solution to analyze cancerous tissues.
The Dark Metabolome: No Mere Figment?

3 weeks ago | theanalyticalscientist.com | James Strachan

In the spring of 2024, Martin Giera, Aries Aisporna, Winnie Uritboonthai, and Gary Siuzdak published a paper arguing that in-source fragmentation (ISF) – the fragmentation of analytes during the initial ionization process within the ESI source – accounts for over 70 percent of the peaks observed in typical LC-MS/MS metabolomic datasets. “This finding disrupts the prevailing assumption that the majority of peaks in mass spectra correspond to unique metabolites,” the authors wrote.
Analysis and Characterization of GLP-1 Peptides

1 month ago | theanalyticalscientist.com | Stephanie Vine

Poor analytical work for GLP-1 peptides during drug development can have serious and far-reaching consequences. One of the most immediate risks is compromised patient safety. If impurities, such as truncated peptides, degradation products, or process related impurities, are not properly identified and controlled, they may lead to adverse immune responses, toxicity, or reduced therapeutic efficacy.
Precision Medicine 2050: With Mike Snyder

1 month ago | theanalyticalscientist.com | James Strachan

Imagine a world where a simple drop of blood, a finger-prick, or a wearable sensor provides a continuous readout of your biological health – without having to visit the hospital. Where AI-powered tools analyze not just your DNA, but your entire molecular profile, to predict risks, guide personalized treatments, and even prevent diseases from developing at all. What would it take to make this vision a reality? What role could analytical science play? And can we get there by 2050?
Precision Medicine 2050: With Ying Ge

1 month ago | theanalyticalscientist.com | James Strachan

What could annual check ups look like in 25 years? Longitudinal analyses of your historical health data to detect early trends, and AI-powered algorithms used to compare biological profiles to that of other patients, grouping individuals into molecular categories for tailored treatment. Imagine a world where a simple drop of blood, a finger-prick, or a wearable sensor provides a continuous readout of your biological health – without having to visit the hospital.
“Western Diet” Fuels Lung Cancer

2 months ago | theanalyticalscientist.com | James Strachan

A study from the University of Florida has identified glycogen as a key metabolic driver of tumor growth in lung adenocarcinoma (LUAD), thanks to a next-generation spatial metabolomics platform. The team, led by Ramon Sun, Associate Professor and Director of the Center for Spatial Biomolecule Research (CASBR), mapped out the precise locations and roles of glycogen – once thought to be a passive energy store – within intact tumor tissues.
Precision Medicine 2050: With Lingjun Li

2 months ago | theanalyticalscientist.com | James Strachan

Imagine a world where a simple drop of blood, a finger-prick, or a wearable sensor provides a continuous readout of your biological health – without having to visit the hospital. Where AI-powered tools analyze not just your DNA, but your entire molecular profile, to predict risks, guide personalized treatments, and even prevent diseases from developing at all. What would it take to make this vision a reality? What role will analytical science play? And can we get there by 2050?