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2 weeks ago | 
theanalyticalscientist.com | Frank van Geel |James Strachan
After a pandemic-induced pause, Riva del Garda (Italy) will once again play host to the (44th) International Symposium on Capillary Chromatography and the (21st) GC×GC Symposia, on May 17–22, 2026. Long-time leader of the event Luigi Mondello shares the driving forces behind the relaunch: a surge in chromatographic innovation, a need for in-person exchange, and a global community eager to reconnect – especially at Riva del Garda. Why have you decided to restart the Riva conference?
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2 weeks ago | 
theanalyticalscientist.com | James Strachan
The debate over the role of in-source fragmentation (ISF) in untargeted metabolomics continues.
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2 weeks ago | 
theanalyticalscientist.com | James Strachan
Following The Analytical Scientist’s interviews with Pieter Dorrestein and Yasin El Abiead, and responses from Martin Giera and Gary Siuzdak, Shuzhao Li offers a clarifying perspective on the role of in-source fragmentation in untargeted metabolomics. For Li – whose recent preprint surveys LC-MS data from human plasma and serum – the real story is less about conflict and more about context.
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3 weeks ago | 
theanalyticalscientist.com | James Strachan
In the spring of 2024, Martin Giera, Aries Aisporna, Winnie Uritboonthai, and Gary Siuzdak published a paper arguing that in-source fragmentation (ISF) – the fragmentation of analytes during the initial ionization process within the ESI source – accounts for over 70 percent of the peaks observed in typical LC-MS/MS metabolomic datasets. “This finding disrupts the prevailing assumption that the majority of peaks in mass spectra correspond to unique metabolites,” the authors wrote.
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1 month ago | 
conexiant.com | James Strachan
Researchers have developed a dental floss pick capable of measuring salivary cortisol levels to analyze stress. Although standard strategies for measuring cortisol levels typically involve blood tests or saliva kits, the new dental floss pairs electropolymerized molecularly imprinted polymers with thread microfluidics to provide noninvasive, real-time results. Researchers developed the point-of-care platform to facilitate effortless, routine stress monitoring as part of daily dental hygiene.
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1 month ago | 
theanalyticalscientist.com | James Strachan
Imagine a world where a simple drop of blood, a finger-prick, or a wearable sensor provides a continuous readout of your biological health – without having to visit the hospital. Where AI-powered tools analyze not just your DNA, but your entire molecular profile, to predict risks, guide personalized treatments, and even prevent diseases from developing at all. What would it take to make this vision a reality? What role could analytical science play? And can we get there by 2050?
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1 month ago | 
theanalyticalscientist.com | James Strachan
What could annual check ups look like in 25 years? Longitudinal analyses of your historical health data to detect early trends, and AI-powered algorithms used to compare biological profiles to that of other patients, grouping individuals into molecular categories for tailored treatment. Imagine a world where a simple drop of blood, a finger-prick, or a wearable sensor provides a continuous readout of your biological health – without having to visit the hospital.
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2 months ago | 
theanalyticalscientist.com | James Strachan
A study from the University of Florida has identified glycogen as a key metabolic driver of tumor growth in lung adenocarcinoma (LUAD), thanks to a next-generation spatial metabolomics platform. The team, led by Ramon Sun, Associate Professor and Director of the Center for Spatial Biomolecule Research (CASBR), mapped out the precise locations and roles of glycogen – once thought to be a passive energy store – within intact tumor tissues.
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2 months ago | 
theanalyticalscientist.com | James Strachan
Imagine a world where a simple drop of blood, a finger-prick, or a wearable sensor provides a continuous readout of your biological health – without having to visit the hospital. Where AI-powered tools analyze not just your DNA, but your entire molecular profile, to predict risks, guide personalized treatments, and even prevent diseases from developing at all. What would it take to make this vision a reality? What role will analytical science play? And can we get there by 2050?
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2 months ago | 
theanalyticalscientist.com | James Strachan
Extra Special EV Protocol One paper that stood out this week: Georg Ramer and colleagues at TU Wien unveiled a new method for analyzing individual extracellular vesicles (EVs). EVs are tough to study because of their small size, heterogeneity, and the limitations of bulk or label-based techniques. The team addressed these challenges using atomic force microscopy infrared spectroscopy (AFM-IR), combined with antibody-based capture, hyperspectral imaging, and machine learning.
