The Clinical Advisor

The Clinical Advisor is a monthly publication designed for nurse practitioners and physician assistants working in primary care. Its goal is to provide these healthcare professionals with current insights on diagnosing, treating, managing, and preventing common conditions encountered in a typical office environment.

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Adjuvant Cemiplimab Could Be New Standard of Care for High-Risk CSCC

1 week ago | clinicaladvisor.com | Erin Clancy

Adjuvant cemiplimab can improve disease-free survival (DFS) in patients with cutaneous squamous cell carcinoma (CSCC) who have completed adjuvant radiotherapy and have a high risk of recurrence, according to research presented at the ASCO Annual Meeting 2025.1 “[C]emiplimab is the only systemic therapy to demonstrate a statistically significant and clinically meaningful reduction in disease recurrence as adjuvant therapy for patients at high risk of CSCC recurrence,” said study presenter...
Amneal Recalls Oral Antibiotic Over Contamination Issue

1 week ago | clinicaladvisor.com | Jaymin Kang

Amneal Pharmaceuticals is recalling 3 lots of Sulfamethoxazole/Trimethoprim Tablets, USP, 400 mg/80 mg due to Aspergillus contamination. Sulfamethoxazole/Trimethoprim is indicated for the treatment of urinary tract infections caused by susceptible strains of Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis and Proteus vulgaris.
Collaborative Care Therapeutic Strategy Most Useful in Primary Care Depression

2 weeks ago | clinicaladvisor.com | Ron Goldberg

Components of collaborative care that most efficaciously reduce depressive symptoms in primary care involve therapeutic treatment strategy including manual-based psychotherapy and family involvement. These meta-analysis study findings were published in JAMA Psychiatry. Collaborative care involves a case manager and primary care physician working together to integrate care and services for patients with depression.
Access to Gender-Affirming Care for Transgender Youth Has Positive Outcomes

2 weeks ago | clinicaladvisor.com | Jessica Nye

Youth identifying as transgender and gender-expansive who have access to social and medical gender-affirming care (GAC) generally had positive outcomes, according to study results presented at the American Psychiatric Association Annual Meeting, held virtually from May 17 to 21, 2025, in Los Angeles, California. Professional medication organizations recommend in evidence-based guidelines that transgender and gender-expansive youth should receive social and medical GAC.
Rilzabrutinib Designated Orphan Drug for Sickle Cell Disease

3 weeks ago | clinicaladvisor.com | Diana Ernst

The Food and Drug Administration (FDA) has granted Orphan Drug designation to rilzabrutinib for the treatment of sickle cell disease. Rilzabrutinib is an investigational, oral, reversible Bruton tyrosine kinase (BTK) inhibitor. Preclinical findings show the drug reduces vaso-occlusion, markers of inflammation, and adhesion in transgenic mice with sickle cell disease.
FDA Approves Moderna’s Next-Generation COVID-19 Vaccine mNexspike

3 weeks ago | clinicaladvisor.com | Diana Ernst

The Food and Drug Administration (FDA) has approved Moderna’s next-generation mRNA COVID-19 vaccine mNexspike®. The new vaccine is indicated for active immunization to prevent COVID-19 caused by SARS-CoV-2 in individuals who have been previously vaccinated with any COVID-19 vaccine and are 65 years or older, or 12 to 64 years of age with at least 1 underlying condition that puts them at high risk for severe outcomes from COVID-19.
Navigating the Changing Landscape of LGBTQ+ Health Care: Q&A With Carlos Gutiérrez, EdD, MMS, PA-C

3 weeks ago | clinicaladvisor.com | Nikki Kean

The Clinical Advisor is celebrating PRIDE Month. To gauge how the changing landscape surrounding diversity, equity, and inclusion (DEI) policy is affecting LGBTQ+ patients, we spoke with Carlos Gutiérrez, EdD, MMS, PA-C. Dr Gutiérrez is an associate professor and vice chair of Student Success for the Department of Physician Assistant Studies at the School of Health and Rehabilitation Sciences, University of Pittsburgh. He is also president of the Arizona State Association of Physician Assistants.
Media Use and Demographic Factors Impact Sleep Duration, Quality in Older Adults

3 weeks ago | clinicaladvisor.com | Ron Goldberg

Sleep duration and sleep quality among older adults may be mediated by media use and demographic factors, according to study results presented at the American Psychiatric Association Annual Meeting, held virtually from May 17 to 21, 2025, in Los Angeles, California. Researchers sought to describe media-use preferences among older adults and how that usage impacts sleep duration and quality.
FDA Authorizes Use of COVID-19 Antibody Therapy for Postexposure Prophylaxis

3 weeks ago | clinicaladvisor.com | Diana Ernst

The Food and Drug Administration (FDA) has authorized the use of REGEN-COV (casirivimab and imdevimab) for postexposure prophylaxis of COVID-19 in individuals (12 years of age and older weighing at least 40kg) who are at high risk for progression to severe COVID-19, including hospitalization or death. The investigational agent was previously granted Emergency Use Authorization (EUA) for the treatment of mild to moderate COVID-19.
MAFLD Is Not Predictive of Survival in Those With Hepatocellular Carcinoma

4 weeks ago | clinicaladvisor.com | Colby Stong

Patients with hepatocellular carcinoma (HCC) who are metabolic-associated fatty liver disease (MAFLD)-positive and MAFLD-negative have similar rates of overall survival (OS) and progression-free survival (PFS) after adjusting for confounding factors, according to study results presented at Digestive Disease Week (DDW), held May 3 to 6, 2025, in San Diego, California.