Matthew Sinton

Nov 18, 2024 | nature.com | Abigail C. Lay |Frédéric Burdet |Florence Mehl |Dmytro Kryvokhyzha |Abrar Ahmad |Matthew Sinton | +9 more

AbstractDiabetic kidney disease (DKD) is the leading cause of end stage kidney failure worldwide, of which cellular insulin resistance is a major driver. Here, we study key human kidney cell types implicated in DKD (podocytes, glomerular endothelial, mesangial and proximal tubular cells) in insulin sensitive and resistant conditions, and perform simultaneous transcriptomics and proteomics for integrated analysis.

Oct 20, 2024 | febs.onlinelibrary.wiley.com | Matthew Sinton |Shingo Kajimura

Introduction The adipose tissue, which was once thought of as an inert energy storage facility, is now understood to exert profound effects on energy balance, through both endocrine signalling and regulation of organismal behaviour.