Abigail L. LaBella

Aug 29, 2024 | nature.com | Pol Sole-Navais |Xiaoping Wu |Marc Vaudel |Abigail L. LaBella |Øyvind Helgeland |Christopher Flatley | +9 more

AbstractJaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it is not clear why some neonates experience more severe jaundice and require treatment with phototherapy. Here, we present the first genome-wide association study of neonatal jaundice to date in nearly 30,000 parent-offspring trios from Norway (cases ≈ 2000).

May 10, 2023 | nature.com | Pol Sole-Navais |Valgerdur Steinthorsdottir |Marc Vaudel |Julius Juodakis |JING CHEN |Triin Laisk | +40 more

Author notesAnubha Mahajan & Mark I. McCarthyPresent address: Genentech, South San Francisco, CA, USAThese authors contributed equally: Ge Zhang, Bo Jacobsson.

Apr 3, 2023 | nature.com | Pol Sole-Navais |Valgerdur Steinthorsdottir |Marc Vaudel |Julius Juodakis |JING CHEN |Triin Laisk | +40 more

AbstractThe timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration.