Øyvind Helgeland

Aug 29, 2024 | nature.com | Pol Sole-Navais |Xiaoping Wu |Marc Vaudel |Abigail L. LaBella |Øyvind Helgeland |Christopher Flatley | +9 more

AbstractJaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it is not clear why some neonates experience more severe jaundice and require treatment with phototherapy. Here, we present the first genome-wide association study of neonatal jaundice to date in nearly 30,000 parent-offspring trios from Norway (cases ≈ 2000).

Feb 8, 2024 | nature.com | Øyvind Helgeland |Marc Vaudel |Pol Sole-Navais |Christopher Flatley |Julius Juodakis |Jonas Bacelis | +8 more

Correction to: Nature Metabolism https://doi.org/10.1038/s42255-022-00549-1, published online 21 March 2022. In the version of the article initially published, there were errors in Supplementary Table 1 where the values in the age column were incorrectly ordered (the values for Q3 were substituted for the values of Q1). The corrected Supplementary Table 1 has now been uploaded. This was an error in formatting and has no implications for the analyses, results or conclusions of the paper.

Oct 5, 2023 | nature.com | Robin Beaumont |Christopher Flatley |Marc Vaudel |JING CHEN |Gunn-Helen Moen |Line Skotte | +52 more

AbstractA well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1.

May 10, 2023 | nature.com | Pol Sole-Navais |Valgerdur Steinthorsdottir |Marc Vaudel |Julius Juodakis |JING CHEN |Triin Laisk | +40 more

Author notesAnubha Mahajan & Mark I. McCarthyPresent address: Genentech, South San Francisco, CA, USAThese authors contributed equally: Ge Zhang, Bo Jacobsson.

Apr 3, 2023 | nature.com | Pol Sole-Navais |Valgerdur Steinthorsdottir |Marc Vaudel |Julius Juodakis |JING CHEN |Triin Laisk | +40 more

AbstractThe timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration.