Christopher Flatley

Dec 5, 2024 | obgyn.onlinelibrary.wiley.com | Christopher Flatley |Dana Kristjansson |Sahlgrenska Academy |Karin Ytterberg

Objective Endometriosis affects 10% of women worldwide and is linked to adverse pregnancy outcomes, including preterm birth. Recent epidemiological and genetic studies indicate that endometriosis may influence gestational duration and the likelihood of preterm birth.

Aug 29, 2024 | nature.com | Pol Sole-Navais |Xiaoping Wu |Marc Vaudel |Abigail L. LaBella |Øyvind Helgeland |Christopher Flatley | +9 more

AbstractJaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it is not clear why some neonates experience more severe jaundice and require treatment with phototherapy. Here, we present the first genome-wide association study of neonatal jaundice to date in nearly 30,000 parent-offspring trios from Norway (cases ≈ 2000).

Jul 22, 2024 | nature.com | David Westergaard |Valgerdur Steinthorsdottir |Palle Duun Rohde |Xiaoping Wu |Frank Geller |Pol Sole-Navais | +22 more

AbstractBleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severe impact on maternal–fetal health. We identified five genetic loci linked to PPH in a meta-analysis.

Feb 8, 2024 | nature.com | Øyvind Helgeland |Marc Vaudel |Pol Sole-Navais |Christopher Flatley |Julius Juodakis |Jonas Bacelis | +8 more

Correction to: Nature Metabolism https://doi.org/10.1038/s42255-022-00549-1, published online 21 March 2022. In the version of the article initially published, there were errors in Supplementary Table 1 where the values in the age column were incorrectly ordered (the values for Q3 were substituted for the values of Q1). The corrected Supplementary Table 1 has now been uploaded. This was an error in formatting and has no implications for the analyses, results or conclusions of the paper.

Oct 5, 2023 | nature.com | Robin Beaumont |Christopher Flatley |Marc Vaudel |JING CHEN |Gunn-Helen Moen |Line Skotte | +52 more

AbstractA well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1.