Adam J. Rauckhorst

Jan 7, 2025 | cell.com | Adam J. Rauckhorst |Ryan D. Sheldon |Daniel J. Pape |Adnan Ahmed |Kelly C Falls-Hubert |Ronald A. Merrill | +6 more

Keywordsmitochondrial pyruvate carrierMPCmitochondrial citrate carrierCiCATP-citrate lyaseACLYacetyl-CoA synthetase 2ACSS2acetoacetyl-CoA synthetaseAACSde novo lipogenesisDNLlivermetabolomicsstable isotope tracersIntroductionDe novo lipogenesis (DNL) is an essential mammalian physiologic process that produces lipids required for membrane structures, signaling, and fuel storage. While most whole-body DNL occurs in adipose tissue and the liver, the liver has less capacity to store fat healthily.