Ryan D. Sheldon

Jan 7, 2025 | cell.com | Adam J. Rauckhorst |Ryan D. Sheldon |Daniel J. Pape |Adnan Ahmed |Kelly C Falls-Hubert |Ronald A. Merrill | +6 more

Keywordsmitochondrial pyruvate carrierMPCmitochondrial citrate carrierCiCATP-citrate lyaseACLYacetyl-CoA synthetase 2ACSS2acetoacetyl-CoA synthetaseAACSde novo lipogenesisDNLlivermetabolomicsstable isotope tracersIntroductionDe novo lipogenesis (DNL) is an essential mammalian physiologic process that produces lipids required for membrane structures, signaling, and fuel storage. While most whole-body DNL occurs in adipose tissue and the liver, the liver has less capacity to store fat healthily.

Apr 16, 2024 | mustreadalaska.com | Ryan D. Sheldon |Suzanne Downing

By RYAN SHELDONSome of you may already know me, and I figured I’d reintroduce myself. I’m Ryan Sheldon of Talkeetna and I’m excited about 2024. Having recently been elected as chairman in Alaska’s District 30 Republican Party (spanning from Point Mackensie to Anderson and Healy), I am optimistic about the things that all Alaskans can be doing to be productive in this highly contested 2024 election season and beyond.

Mar 22, 2024 | cell.com | James Schofield |Notre Dame |Joseph Longo |Ryan D. Sheldon

Highlights•Cancerous epithelial cells can express Acod1 and produce itaconate•Acod1 loss in αPD-1-resistant tumors resensitizes them to therapy•Acod1hi cells inhibit naive CD8+ T cell activation independent of itaconate•Acod1hi cells suppress T cells by secreting inhibitory peptidesSummaryTargeting programmed cell death protein 1 (PD-1) is an important component of many immune checkpoint blockade (ICB) therapeutic approaches.

Aug 8, 2023 | adn.com | Ryan D. Sheldon

We have an opportunity to capitalize on the expertise of our state's Permanent Fund managers.