Kelly C Falls-Hubert

Jan 7, 2025 | cell.com | Adam J. Rauckhorst |Ryan D. Sheldon |Daniel J. Pape |Adnan Ahmed |Kelly C Falls-Hubert |Ronald A. Merrill | +6 more

Keywordsmitochondrial pyruvate carrierMPCmitochondrial citrate carrierCiCATP-citrate lyaseACLYacetyl-CoA synthetase 2ACSS2acetoacetyl-CoA synthetaseAACSde novo lipogenesisDNLlivermetabolomicsstable isotope tracersIntroductionDe novo lipogenesis (DNL) is an essential mammalian physiologic process that produces lipids required for membrane structures, signaling, and fuel storage. While most whole-body DNL occurs in adipose tissue and the liver, the liver has less capacity to store fat healthily.

Sep 13, 2024 | biorxiv.org | Daniel J. Pape |Ronald A. Merrill |Adnan Ahmed |Kelly C Falls-Hubert

AbstractHepatic gluconeogenesis (GNG) is essential for maintaining euglycemia during prolonged fasting. However, GNG becomes pathologically elevated and drives chronic hyperglycemia in type 2 diabetes (T2D). Lactate/pyruvate is a major GNG substrate known to be imported into mitochondria for GNG. Yet, the subsequent mitochondrial carbon export mechanisms required to supply the extra-mitochondrial canonical GNG pathway have not been genetically delineated.