Adam Sachs

Jun 11, 2024 | nytimes.com | Adam Sachs

GRETEL AND THE GREAT WAR, by Adam Ehrlich SachsInterwar Austria - baroque, violent, demented, doomed - flickers into view in Adam Ehrlich Sachs's new novel, "Gretel and the Great War." No staid work of history, this. Sachs draws from the madcap, darkly comic tradition of postmodern European fiction to reimagine the continent's catastrophic destiny. The novel opens in November 1919, when Gretel, a young mute girl, is found wandering the streets of Vienna.

May 28, 2024 | countercraft.substack.com | Adam Sachs |Nicholson Baker |Samanta Schweblin |Percival L. Everett

Hi everyone, I’m back from a brief hiatus in which I read some good, weird books. One of them was a galley of the novel Gretel and the Great Warby Adam Ehrlich Sachs—coming out from FSG this summer—that is set in 1919 Austria and composed of letters from a man in a sanatorium to a mute woman he claims is his daughter. I really enjoyed the novel, which feels a bit like Brothers Grimm meets Thomas Bernhard, and especially admired its tricky form.

May 18, 2024 | theatlantic.com | Adam Sachs

The girl’s expressive gifts surpass those of all the members of his company, even the aging starlet Klamt. That is something the General Intendant of the City Theater can no longer deny. Up to this point, he has done everything in his power to keep his daughter off the stage, for the General Intendant is intimately acquainted with the unscrupulousness of theater people and is well aware that if he casts her in a leading role, she will be subjected to the most malicious slander. And so will he.

Apr 30, 2024 | biorxiv.org | Adam Sachs |Sunil Kumar |Emily G Oldani |Erich G Chapman

AbstractThe events that lead to protein misfolding diseases are poorly understood. Many proteins implicated in neurodegenerative diseases (e.g., TDP43) interact with nucleic acids, including RNA G-quadruplexes. In this work, we investigate whether RNA G-quadruplexes play a role in TDP43 aggregation in biophysical and cellular models. We find that G-quadruplexes modulate TDP43 aggregation in a biophysical model and in multiple cell types, including yeast, HEK293T, and motor-neuron-like NSC-34 cells.

Apr 15, 2024 | discover.silversea.com | Adam Sachs

S.A.L.T. (Sea and Land Taste) is all about connecting guests to destinations through the lens of food and the people, rituals and flavors behind culinary traditions. And where better to launch a program that’s all about the roots of deliciousness than in Greece, where the endless bounty of the sea meets the ancient culture and traditions of the sun-baked coast? In the land of Dionysus, winemaking has a long and storied history.