Sunil Kumar

2 weeks ago | biorxiv.org | Emily G Oldani |Adam Sachs |Erich G Chapman |Sunil Kumar

AbstractThe events that lead to protein misfolding diseases are not fully understood. Many proteins implicated in neurodegenerative diseases (e.g., TDP43) interact with nucleic acids, including RNA G-quadruplexes. In this work, we investigate whether RNA G-quadruplexes play a role in TDP43 condensation in biophysical and cellular models.