Adolfo Garcia-Sastre

Nov 4, 2024 | sciencenorway.no | Adolfo Garcia-Sastre

The case in short Flu causes 5 million hospitalisations annually worldwide. Pandemic flu strains emerge from animal reservoirs. H5N1 spreads widely, adapting to infect mammals. We need universal vaccines to prevent future pandemics. Most people associate influenza virusinfections with a respiratory cold that sometimes comes with fever and malaise, often requiring bed rest for a couple of days.

Aug 31, 2023 | biorxiv.org | Hemant Joshi |Andrew Baessler |Ignacio Mena |Adolfo Garcia-Sastre

AbstractCurrent influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity. Due to the necessity of germinal center formation in generating long-lived high affinity antibodies, the germinal center has increasingly become a target for the development of novel or improvement of less-efficacious vaccines.