Andrew Baessler

Aug 31, 2023 | biorxiv.org | Hemant Joshi |Andrew Baessler |Ignacio Mena |Adolfo Garcia-Sastre

AbstractCurrent influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity. Due to the necessity of germinal center formation in generating long-lived high affinity antibodies, the germinal center has increasingly become a target for the development of novel or improvement of less-efficacious vaccines.