Adrian J. Mulholland

Dec 3, 2023 | biorxiv.org | Adrian J. Mulholland |Christopher J Schofield |Fernanda Duarte

AbstractThe main protease (Mpro) of the SARS-CoV-2 coronavirus employs a cysteine-histidine dyad in its active site to catalyse hydrolysis of the viral polyproteins. It is well established that binding of the substrate P1-Gln in the S1 subsite of Mpro active site is crucial for catalysis and this interaction has been employed to inform inhibitor design; however, how Mpro dynamically recognises and responds to substrate binding remains difficult to probe by experimental methods.

Jul 17, 2023 | rsc.org | Adrian J. Mulholland |Nick Turner

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