Fernanda Duarte

Dec 3, 2023 | biorxiv.org | Adrian J. Mulholland |Christopher J Schofield |Fernanda Duarte

AbstractThe main protease (Mpro) of the SARS-CoV-2 coronavirus employs a cysteine-histidine dyad in its active site to catalyse hydrolysis of the viral polyproteins. It is well established that binding of the substrate P1-Gln in the S1 subsite of Mpro active site is crucial for catalysis and this interaction has been employed to inform inhibitor design; however, how Mpro dynamically recognises and responds to substrate binding remains difficult to probe by experimental methods.

May 1, 2023 | nature.com | Tatiana Rogova |Kirsten Christensen |Fernanda Duarte |Ken Yamazaki

AbstractMolecules that contain a stereogenic phosphorus atom are crucial to medicine, agrochemistry and catalysis. While methods are available for the selective construction of various chiral organophosphorus compounds, catalytic enantioselective approaches for their synthesis are far less common.