Aflac Cancer

Oct 24, 2024 | aamds.org | Bristol Myers Squibb |Aflac Cancer

Abatacept plus calcineurin inhibitors/methotrexate (CNI/MTX) is the first US Food and Drug Administration (FDA)-approved regimen for acute graft-versus-host disease (aGVHD) prophylaxis during unrelated-donor hematopoietic cell transplantation (URD-HCT). Using Center for International Blood and Marrow Transplant Research data, we investigated its impact in patients receiving 7/8 HLA-mismatched unrelated donor (MMUD) or 8/8 HLA-matched unrelated donor (MUD) URD-HCT between 2011 and 2018.

May 14, 2024 | ashpublications.org | Aflac Cancer

Hemophagocytic lymphohistiocytosis (HLH) is a rare, potentially life-threatening, hyperinflammatory syndrome of which primary features are pathologic immune activation and hyperinflammation accompanied by the release of proinflammatory cytokines, such as interferon gamma (IFN-γ).1-5 Common symptoms include high fever, hepatosplenomegaly, cytopenia, coagulopathy, seizures, and multiorgan failure.1,2,6-8 The hyperinflammatory response in HLH generally manifests in response to an immunogenic...

May 9, 2024 | ashpublications.org | Aflac Cancer

Activation of von Willebrand factor (VWF) is a tightly controlled process governed primarily by local elements around its A1 domain. Recent studies suggest that the O-glycosylated sequences flanking the A1 domain constitute a discontinuous and force-sensitive autoinhibitory module (AIM), although its extent and conformation remains controversial. Here, we used a targeted screening strategy to identify 2 groups of nanobodies.

Oct 15, 2023 | genomemedicine.biomedcentral.com | Aflac Cancer

ReferencesAlexander TB, Orgel E. Mixed phenotype acute leukemia: current approaches to diagnosis and treatment. Curr Oncol Rep. 2021;23(2):22. PubMed  Google Scholar  Maruffi M, Sposto R, Oberley MJ, Kysh L, Orgel E. Therapy for children and adults with mixed phenotype acute leukemia: a systematic review and meta-analysis. Leukemia. 2018;32(7):1515–28. PubMed  PubMed Central  Google Scholar  Raikar SS, Park SI, Leong T, Jaye DL, Keller FG, Horan JT, et al.

Oct 5, 2023 | publications.aap.org | Aflac Cancer

BACKGROUND AND OBJECTIVES:Multisystem inflammatory syndrome in children (MIS-C) is a novel, severe condition following severe acute respiratory syndrome coronavirus 2 infection. Large epidemiologic studies comparing MIS-C to Kawasaki disease (KD) and evaluating the evolving epidemiology of MIS-C over time are lacking.